Global Pushback Against Tyranny Has Begun

March 20, 2021, on the 1-year anniversary of the first COVID-19 lockdown, people in more than 40 countries took to the streets to peacefully demonstrate against COVID-19 lies and tyrannical measures. The documentary above, "The Pushback," details the day the world stood together against government overreach and the destruction of human rights — and why we must unite, every day, and push back. Chances are, you didn't hear about this global rallying cry for freedom, as the mainstream media have near-universally censored any news of it. The few that did report it either understated the global nature of the event and its attendance, or misrepresented the intent of this "Worldwide Freedom Day." Freedom From Fear So, just what was the intent behind this global demonstration? In short, to tell our elected officials and unelected global leaders that we withdraw our consent to these unconstitutional overreaches and attempts to strip us of our rights and freedoms, and that we will no longer submit to and cower in fear. As noted in the film, fear and hysteria were carefully nurtured using a false narrative that said: A deadly novel virus is sweeping across the planet No one is immune and there's no cure Asymptomatic people are major disease vectors, and therefore: We have to shut everything down, isolate everyone and wear masks until the whole world has been vaccinated And, of course, anyone who challenges this crazy narrative is labeled a danger to society. Every part of this narrative is false and unrealistic. In reality: SARS-CoV-2 poses a high risk to a very limited group of people and a negligible risk to the vast majority Few are susceptible to severe illness or death There are several effective treatments available Asymptomatic people — historically known as healthy people — do not spread the infection Lockdowns and mask mandates did not work and have caused great harm Vulnerable people have been harmed instead of helped Ground Zero of the False Narrative March 3, 2020, the World Health Organization tweeted out a comment by WHO director-general Tedros Adhanom Ghebreyesus, which said: "Globally, about 3.4% of reported COVID-19 cases have died. By comparison, seasonal flu generally kills far fewer than 1% of those infected." It makes COVID-19 sound like a serious problem indeed. The problem is that Ghebreyesus compared apples and oranges. He reported the case fatality rate (CFR) of COVID-19, versus the infection fatality rate (IFR) for the flu. As explained in the film, CFR is the proportion of deaths from a disease compared to the number of people diagnosed (the total number of confirmed cases). The IFR, meanwhile, is the proportion of deaths from a disease compared to the total number of infected individuals, confirmed or suspected. Since CFR requires the infection to be confirmed through laboratory testing and clinical evaluation, and the total number of infected people can be hard to determine and includes suspected cases, the CFR is always lower than the IFR. By conflating CFR and IFR in the same sentence, comparing two different sets of statistics, Ghebreyesus grossly overstated the threat of COVID-19. Stanford University researcher John Ioannidis pointed this out in a March 7, 2020, response, in which he said, "Reported case fatality rates, like the official 3.4% rate from the WHO, cause horror — and are meaningless." October 14, 2020, Ioannidis published a review of 61 seroprevalence studies1 showing that the IFR for COVID-19 was actually only 0.23% — a far cry from the CFR of 3.4% — and for people under the age of 70, the IFR was just 0.05%. In other words, COVID-19 is actually less deadly than the flu. Many have noted that the IFR for flu is typically only around 0.1%, and even at that, COVID-19 is less deadly for people under the age of 70. PCR Test Added Fuel to the False Narrative As noted in the documentary, at this point, there are so many false narratives it's hard to know where to begin, but a good place is the reverse transcription polymerase chain reaction (RT-PCR) test, as it is at the heart of this scam. If it weren't for this flawed test, there would be no pandemic to speak of. The fact is, the PCR test is not designed to be used as a diagnostic tool as it cannot distinguish between inactive viruses and "live" or reproductive ones.2 This is a crucial point, since inactive and reproductive viruses are not interchangeable in terms of infectivity. If you have a nonreproductive virus in your body, you will not get sick and you cannot spread it to others. What's more, the test was developed using nothing more than computer modeling of a genetic sequence. No actual viral isolate from a patient was ever used in the development of this test. November 30, 2020, a team of 22 international scientists published a review3 challenging the scientific paper4 on PCR testing for SARS-CoV-2 written by Christian Drosten, Ph.D., and Victor

Global Pushback Against Tyranny Has Begun

March 20, 2021, on the 1-year anniversary of the first COVID-19 lockdown, people in more than 40 countries took to the streets to peacefully demonstrate against COVID-19 lies and tyrannical measures.

The documentary above, "The Pushback," details the day the world stood together against government overreach and the destruction of human rights — and why we must unite, every day, and push back.

Chances are, you didn't hear about this global rallying cry for freedom, as the mainstream media have near-universally censored any news of it. The few that did report it either understated the global nature of the event and its attendance, or misrepresented the intent of this "Worldwide Freedom Day."

Freedom From Fear

So, just what was the intent behind this global demonstration? In short, to tell our elected officials and unelected global leaders that we withdraw our consent to these unconstitutional overreaches and attempts to strip us of our rights and freedoms, and that we will no longer submit to and cower in fear. As noted in the film, fear and hysteria were carefully nurtured using a false narrative that said:

  • A deadly novel virus is sweeping across the planet
  • No one is immune and there's no cure
  • Asymptomatic people are major disease vectors, and therefore:
  • We have to shut everything down, isolate everyone and wear masks until the whole world has been vaccinated

And, of course, anyone who challenges this crazy narrative is labeled a danger to society. Every part of this narrative is false and unrealistic. In reality:

SARS-CoV-2 poses a high risk to a very limited group of people and a negligible risk to the vast majority

Few are susceptible to severe illness or death

There are several effective treatments available

Asymptomatic people — historically known as healthy people — do not spread the infection

Lockdowns and mask mandates did not work and have caused great harm

Vulnerable people have been harmed instead of helped

Ground Zero of the False Narrative

March 3, 2020, the World Health Organization tweeted out a comment by WHO director-general Tedros Adhanom Ghebreyesus, which said:

"Globally, about 3.4% of reported COVID-19 cases have died. By comparison, seasonal flu generally kills far fewer than 1% of those infected."

It makes COVID-19 sound like a serious problem indeed. The problem is that Ghebreyesus compared apples and oranges. He reported the case fatality rate (CFR) of COVID-19, versus the infection fatality rate (IFR) for the flu.

As explained in the film, CFR is the proportion of deaths from a disease compared to the number of people diagnosed (the total number of confirmed cases). The IFR, meanwhile, is the proportion of deaths from a disease compared to the total number of infected individuals, confirmed or suspected.

Since CFR requires the infection to be confirmed through laboratory testing and clinical evaluation, and the total number of infected people can be hard to determine and includes suspected cases, the CFR is always lower than the IFR.

By conflating CFR and IFR in the same sentence, comparing two different sets of statistics, Ghebreyesus grossly overstated the threat of COVID-19. Stanford University researcher John Ioannidis pointed this out in a March 7, 2020, response, in which he said, "Reported case fatality rates, like the official 3.4% rate from the WHO, cause horror — and are meaningless."

October 14, 2020, Ioannidis published a review of 61 seroprevalence studies1 showing that the IFR for COVID-19 was actually only 0.23% — a far cry from the CFR of 3.4% — and for people under the age of 70, the IFR was just 0.05%. In other words, COVID-19 is actually less deadly than the flu. Many have noted that the IFR for flu is typically only around 0.1%, and even at that, COVID-19 is less deadly for people under the age of 70.

PCR Test Added Fuel to the False Narrative

As noted in the documentary, at this point, there are so many false narratives it's hard to know where to begin, but a good place is the reverse transcription polymerase chain reaction (RT-PCR) test, as it is at the heart of this scam. If it weren't for this flawed test, there would be no pandemic to speak of.

The fact is, the PCR test is not designed to be used as a diagnostic tool as it cannot distinguish between inactive viruses and "live" or reproductive ones.2 This is a crucial point, since inactive and reproductive viruses are not interchangeable in terms of infectivity. If you have a nonreproductive virus in your body, you will not get sick and you cannot spread it to others.

What's more, the test was developed using nothing more than computer modeling of a genetic sequence. No actual viral isolate from a patient was ever used in the development of this test.

November 30, 2020, a team of 22 international scientists published a review3 challenging the scientific paper4 on PCR testing for SARS-CoV-2 written by Christian Drosten, Ph.D., and Victor Corman. The Corman-Drosten paper was quickly accepted by the WHO and the workflow described therein was adopted as the standard across the world.

The 22 scientists demanded the Corman-Drosten paper be retracted due to "fatal errors,"5 one of which is the fact that it was written (and the test itself developed) before any viral isolate was available. All they used was the genetic sequence published online by Chinese scientists in January 2020.

As if that doesn't make the test unreliable enough, laboratories were instructed to amplify the RNA collected far too many times, resulting in healthy people testing "positive." The number of amplifications is known as the cycle threshold (CT).

When you get a positive result using a CT of 35 or higher, you're looking at the equivalent of a single copy of viral DNA. The likelihood of that causing a health problem is minuscule. Yet the WHO,6,7,8 the U.S. Food and Drug Administration and the U.S. Centers for Disease Control and Prevention9 were recommending CTs between 40 and 45, thereby guaranteeing a vast majority of "cases" were in fact false positives.

How the Greatest Hoax in History Was Fashioned

As detailed in the featured film, widespread PCR testing gave the mainstream media the fodder needed to create hysteria. For months on end, every broadcast had a tickertape showing the number of "cases" detected.

Other fear-induction tactics included universal masking and 6-foot social distancing rules, replete with plastic barriers everywhere and signs on every floor telling you where to stand and in which direction to walk.

One of the primary tactics that drove the narrative that masking and social distancing were necessities was the lie that asymptomatic people were spreading the infection. Anyone could be a lethal threat. No one was to be exempted from suspicion.

That old man with a cough? Lethal threat. That muscular jogger, flushed from fresh air and exercise? Lethal threat. That pink-faced precocious 2-year-old? Lethal threat. A fearful public soaked up the propaganda and started verbally and physically attacking non-maskers without regard for logic, reason or science.

Without the PCR fraud and the asymptomatic spreader lie, the COVID-19 pandemic would have been a short-lived blip. The lies were able to stand for one reason and one reason only, and that was the implementation of universal censorship of anyone who spoke the truth and pointed out the scientific fallacies that were driving the pandemic narrative.

With these psychological tools — preceded by a single carefully crafted revision of the definition of "pandemic" a decade ago — they manufactured the greatest hoax the world has ever seen. Indeed, you could say the redefinition of pandemic was what brought us to this precipice in the first place. The WHO's original definition of a pandemic was:10,11

"… when a new influenza virus appears against which the human population has no immunity, resulting in several, simultaneous epidemics worldwide with enormous numbers of deaths and illness."

The key portion of that definition is "enormous numbers of deaths and illness." This definition was changed in the month leading up to the 2009 swine flu pandemic. The change was a simple but substantial one: They merely removed the severity and high mortality criteria, leaving the definition of a pandemic as "a worldwide epidemic of a disease."12

By removing the criteria of severe illness causing high morbidity, leaving geographically widespread infection as the only criteria for a pandemic, the WHO and technocratic leaders of the world were able to bamboozle the global population into believing we were in mortal danger.

What Works and What Doesn't

The total discarding of science is perhaps the most perplexing part of this pandemic. We're told to follow the science, but what they actually mean is that we must do as we're told, without evidence. As noted in the film, we've long known what works and what doesn't, when it comes to pandemic disease mitigation.

Effective measures include hand-washing and isolating the sick. Everything we've been told to do over this past year falls squarely in the "proven ineffective" category, and that includes large scale quarantines, border closures, school closures, social distancing and universal mask use. What's worse, everything we've been told that is necessary to save lives, actually fuels disease.

What Was the Pandemic Really About?

In my best-selling book, "The Truth About COVID-19 — Exposing the Great Reset, Lockdowns, Vaccine Passports and the New Normal," I detail the backstory of how the COVID-19 pandemic was created and, more importantly, why. If you do not understand the geopolitical landscape we're in right now, you will struggle to understand why anyone would possibly lie about a virus and create a pandemic out of smoke and mirrors.

In a nutshell, a small but highly organized technocratic elite have used this pandemic as a justification for eroding liberty, freedom and democracy from Day 1, and the reason is because they want to usher in a whole new global system. The global elite refer to this new system as the Great Reset, the Fourth Industrial Revolution and the Build Back Better plan.

Make no mistake, the plan — as laid out in various papers and reports, including s 2010 Rockefeller Foundation report,13 in which they describe their "Lockstep" scenario, which is a coordinated global response to a lethal pandemic, and its 2020 white paper,14 "National COVID-19 Testing Action Plan" — is to use bioterrorism to take control of the world's resources, wealth and people.

The plan is to use the need for coordinated pandemic response as the justification for permanent surveillance and social controls that hobble personal liberty and freedom of choice.

To learn more about the hidden power structure running this global reorganization toward authoritarian control, see "Bill Gates Wants to Realize Global Vision in His Lifetime," "The Great Reset and Build Back Better," "Technocracy and the Great Reset" and "Who Pressed the Great Reset Button?"

The Time to Stand for Freedom Is Right NOW

In 2007, Naomi Wolf published "The End of America: Letter of Warning to a Young Patriot," in which she lays out the 10 steps to tyranny. She's now warning everyone, everywhere, that we are at Step 10. Once Step 10 locks into place, there's no going back. It'll be too dangerous to fight back.

Right now, you might face police brutality or censorship. If that dissuades you from doing your part in standing against the totalitarian dictates right now, in the future, you'll lose everything.

The good news is the would-be tyrants have not won yet. That said, we have no time to spare. We have no time to remain idle, hoping it will all just go back to normal on its own. In countries where citizens do not have a Second Amendment right to bear arms, the answer is peaceful mass civil disobedience.

In the U.S., we do have the Second Amendment, which allows citizens to own and bear arms, and the mere possibility of an armed uprising makes it more difficult for a tyrannical government to get their way. That said, peaceful disobedience is the primary strategy in armed countries as well.

We must also rally behind legislation that prevents the alteration of laws that safeguard our freedoms. To that end, Wolf has started the Five Freedoms Campaign, which you can find on her Daily Clout website.

The campaign focuses on creating legislation to preserve key freedoms and prevent emergency laws from infringing on our freedom to assemble, worship, protest and engage in business. Legislation is also being crafted to open schools, remove mask mandates and eliminate requirements for vaccine passports.

Hope, in the Face of Tyranny

I have no doubt that we will ultimately stop the globalists' drive toward global tyranny. It's not going to be easy. It may take years, and it may get far worse before it gets better.

The founders of the U.S. fled repressive societies or were children or grandchildren of those who did. They had to personally reckon with criminalized speech, arbitrary arrests and state sanctioned torture and even murder. The men who signed the Declaration of Independence knew that if they lost the war, they would be executed for treason.

These men and women were radicals, fighting for liberty and personal freedoms. They had a vision of reality that was an absolute slap in the face of what the rest of the world tolerated. They were willing to sacrifice their lives to turn that vision into a reality. Most all of us have forgotten their sacrifices and have capitulated to the carefully constructed narrative to create fear that allows most to give up their claim to freedom.

The Founders trusted us to remember our history and remain ever vigilant, to keep the precious web of liberty and personal freedom that they constructed from evaporating so that there would never be an American tyrant. The creators of the U.S. Constitution understood that the price of liberty was eternal vigilance.

Hopefully, enough people will see through the mainstream fog and see the truth of where we're headed and how we got here (if you don't, read "The Truth About COVID-19"), and once you understand who the actual enemy is, you become less fearful and more efficient. You can now help educate others, so that they understand what's going on, how they're being deceived and what they're actually about to give up.

Lastly, there are legal solutions that can help thwart the globalist takeover, technological solutions that can strengthen citizens' lobbying power, and censor-proof technologies that will allow us to circumvent current Big Tech monopolies. We have to work on all of these fronts but, together, I believe we can resecure freedom for our children and future generations.

Source : Mercola More   

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Costly Spice Surprisingly Effective for Alzheimer's

Saffron is one of the most expensive spices in the world, and for good reason. Evidence suggests this unique and costly spice may have a significant impact on the development and progression of Alzheimer’s disease.1 Saffron is harvested from the stigma of Crocus sativus, a perennial plant belonging to the iris family. The flower has three stigmas of saffron that must be harvested while the flowers are still closed, during the one week every year when the plant flowers.2 It is believed that saffron is native to Greece, but today most of the spice is grown in Iran, Greece, Morocco and India.3 The spice has a complex flavor profile that is difficult to describe. On its own, saffron smells woody with an earthy scent.4 To buy the real deal, saffron can cost up to $13 per gram, or about $365 per ounce.5 To produce 1 ounce of saffron takes 3,000 stigmas, or 1,000 flowers. When you're buying saffron, look for a dark red or red orange color in which you should be able to see individual threads. If you found a cheaper saffron, it's likely fake.6 The stigmas from safflower plants are sometimes substituted and sold less expensively. They do not add the same color or flavor profile to foods, although they smell a little like saffron. Real saffron is sometimes adulterated by grinding up and mixing safflower stigmas to stretch the product. Saffron as Effective as Drug Against Severe Alzheimer’s Saffron has historically been used in Persian traditional medicine for the treatment of memory problems. Multiple animal studies have looked at the antioxidant protection saffron may offer along with its protection against cognitive decline and memory deficits.7 In one animal study, researchers used morphine to induce memory loss and found the administration of saffron attenuated the impairment.8 In another study,9 researchers found that animals injected with saffron extract, including the active ingredient crocin, and subsequently subjected to stress, exhibited:10 “… significantly higher activities of antioxidant enzymes including glutathione peroxidase, glutathione reductase and superoxide dismutase and significantly lower total antioxidant reactivity capacity. Finally, crocin significantly decreased plasma levels of corticosterone, as measured after the end of stress. These observations indicate that saffron and its active constituent crocin can prevent the impairment of learning and memory as well as the oxidative stress damage to the hippocampus induced by chronic stress.” The main compound, crocin, is a water-soluble carotenoid that has demonstrated potential to protect brain cells in animal and lab studies.11 Saffron extract was tested12 against memantine, a commonly prescribed medication for the symptoms of moderate to severe Alzheimer's disease. Memantine is an NMDA receptor antagonist that has demonstrated the ability to slow the loss of cognitive abilities.13 Like most medications, memantine has a list of side effects, including vomiting, loss of appetite, unusual weakness, anxiety and aggression.14 Some of these side effects are also common symptoms of moderate-to-severe Alzheimer's disease, including anxiety and aggression.15 Researchers engaged 68 people with a diagnosis of moderate-to-severe Alzheimer's disease.16 The group was split into a treatment group and a control group. The control group received memantine at a dose of 20 milligrams (mg) per day while the intervention group received 30 mg per day of saffron capsules for 12 months. Adverse events related to the intervention or medication were recorded and the participants’ cognitive skills were evaluated every month. The researchers found no statistically significant difference between the two groups. They concluded the saffron extract capsules were “comparable with memantine in reducing cognitive decline in patients with moderate to severe AD.”17 Researchers have been looking at the mechanism of action crocin may take in the brain. During the development and progression of Alzheimer's disease, tangles and amyloid plaques aggregate in the brain and destroy brain nerve cell function. One lab study18 demonstrated crocin has a protective effect on the development of amyloid plaque commonly found with Alzheimer's disease. It not only inhibits the formation but disrupts current aggregates of amyloid in the brain. Other hallmarks of the disease are the fibril tangles made of tau protein. Another lab study19 demonstrated crocin had an inhibitory effect on the formation and aggregation of tau protein filaments. Alzheimer’s Disease Linked to Insulin Resistance The Alzheimer's Association20 estimates there are more than 6 million people living in the U.S. who currently have a diagnosis of Alzheimer's disease. The number is projected to more than double to nearly 13 million by 2050. During 2020, the association estimated Alzheimer's and dementia deaths increased by 16%, with 1 in 3 seniors dyin

Costly Spice Surprisingly Effective for Alzheimer's

Saffron is one of the most expensive spices in the world, and for good reason. Evidence suggests this unique and costly spice may have a significant impact on the development and progression of Alzheimer’s disease.1

Saffron is harvested from the stigma of Crocus sativus, a perennial plant belonging to the iris family. The flower has three stigmas of saffron that must be harvested while the flowers are still closed, during the one week every year when the plant flowers.2

It is believed that saffron is native to Greece, but today most of the spice is grown in Iran, Greece, Morocco and India.3 The spice has a complex flavor profile that is difficult to describe. On its own, saffron smells woody with an earthy scent.4

To buy the real deal, saffron can cost up to $13 per gram, or about $365 per ounce.5 To produce 1 ounce of saffron takes 3,000 stigmas, or 1,000 flowers. When you're buying saffron, look for a dark red or red orange color in which you should be able to see individual threads.

If you found a cheaper saffron, it's likely fake.6 The stigmas from safflower plants are sometimes substituted and sold less expensively. They do not add the same color or flavor profile to foods, although they smell a little like saffron. Real saffron is sometimes adulterated by grinding up and mixing safflower stigmas to stretch the product.

Saffron as Effective as Drug Against Severe Alzheimer’s

Saffron has historically been used in Persian traditional medicine for the treatment of memory problems. Multiple animal studies have looked at the antioxidant protection saffron may offer along with its protection against cognitive decline and memory deficits.7

In one animal study, researchers used morphine to induce memory loss and found the administration of saffron attenuated the impairment.8 In another study,9 researchers found that animals injected with saffron extract, including the active ingredient crocin, and subsequently subjected to stress, exhibited:10

“… significantly higher activities of antioxidant enzymes including glutathione peroxidase, glutathione reductase and superoxide dismutase and significantly lower total antioxidant reactivity capacity. Finally, crocin significantly decreased plasma levels of corticosterone, as measured after the end of stress.

These observations indicate that saffron and its active constituent crocin can prevent the impairment of learning and memory as well as the oxidative stress damage to the hippocampus induced by chronic stress.”

The main compound, crocin, is a water-soluble carotenoid that has demonstrated potential to protect brain cells in animal and lab studies.11 Saffron extract was tested12 against memantine, a commonly prescribed medication for the symptoms of moderate to severe Alzheimer's disease. Memantine is an NMDA receptor antagonist that has demonstrated the ability to slow the loss of cognitive abilities.13

Like most medications, memantine has a list of side effects, including vomiting, loss of appetite, unusual weakness, anxiety and aggression.14 Some of these side effects are also common symptoms of moderate-to-severe Alzheimer's disease, including anxiety and aggression.15

Researchers engaged 68 people with a diagnosis of moderate-to-severe Alzheimer's disease.16 The group was split into a treatment group and a control group. The control group received memantine at a dose of 20 milligrams (mg) per day while the intervention group received 30 mg per day of saffron capsules for 12 months.

Adverse events related to the intervention or medication were recorded and the participants’ cognitive skills were evaluated every month. The researchers found no statistically significant difference between the two groups. They concluded the saffron extract capsules were “comparable with memantine in reducing cognitive decline in patients with moderate to severe AD.”17

Researchers have been looking at the mechanism of action crocin may take in the brain. During the development and progression of Alzheimer's disease, tangles and amyloid plaques aggregate in the brain and destroy brain nerve cell function. One lab study18 demonstrated crocin has a protective effect on the development of amyloid plaque commonly found with Alzheimer's disease.

It not only inhibits the formation but disrupts current aggregates of amyloid in the brain. Other hallmarks of the disease are the fibril tangles made of tau protein. Another lab study19 demonstrated crocin had an inhibitory effect on the formation and aggregation of tau protein filaments.

Alzheimer’s Disease Linked to Insulin Resistance

The Alzheimer's Association20 estimates there are more than 6 million people living in the U.S. who currently have a diagnosis of Alzheimer's disease. The number is projected to more than double to nearly 13 million by 2050. During 2020, the association estimated Alzheimer's and dementia deaths increased by 16%, with 1 in 3 seniors dying with Alzheimer's or another form of dementia.

This is estimated to cost the U.S. $355 billion in 2021 and may rise as high as $1.1 trillion by 2050. Besides Alzheimer’s disease, diseases such as cardiovascular disease, obesity and Type 2 diabetes have also been growing significantly in the past several decades.

The interaction between aging and insulin resistance may increase the risk of Alzheimer's disease.21 Scientists began calling the form of diabetes that selectively involves the brain Type 3 diabetes and concluded that the features of this condition raise the risk of Alzheimer's disease.22

By 2015, researchers from Iowa State University23 found a strong association between an individual's memory function decline and insulin resistance, which added to the growing body of evidence that preventing insulin resistance is an important means of preventing Alzheimer's disease. A study scientist from the department of food science and human nutrition at Iowa State commented in a press release:24

"We are terrible at adjusting our behavior based on what might happen in the future. That's why people need to know that insulin resistance or related problems with metabolism can have an effect in the here and now on how they think, and it's important to treat.

For Alzheimer's, it's not just people with Type 2 diabetes. Even people with mild or moderate insulin resistance who don't have Type 2 diabetes might have an increased risk for Alzheimer's disease because they're showing many of the same sorts of brain and memory relationships."

In the following years, more evidence was found to link insulin resistance with Alzheimer's disease. Type 2 diabetes substantially increases the risk of neurodegenerative dementia and especially Alzheimer's disease.25

Scientists continue to analyze the way insulin affects the brain and find it increases the turnover of neurotransmitters and influences the clearance of the hallmarks of Alzheimer’s disease — amyloid beta peptide and phosphorylation of tau.26 Insulin is thought to have an effect on multiple pathways that contribute to neurodegeneration.

Saffron Aids Insulin Sensitivity and Lowers Blood Glucose

Saffron contributes to reducing the development and progression of Alzheimer’s disease through reducing insulin resistance. In one review of the literature,27 researchers identified animal studies in which the bioactive compound crocin helps reduce insulin resistance. This happened when the animals were administered dexamethasone or a high fructose diet to induce high blood sugar.

One laboratory study28 suggested saffron may help glucose uptake into the muscle, but when administered with insulin, improved insulin sensitivity. Evidence from the cell study suggested that AMP-activated protein kinase (AMPK) is a mechanism that plays a major role in the effect saffron has on insulin sensitivity in skeletal muscle cells.

Animal studies29 have also demonstrated that saffron extract can lower blood glucose levels and have a positive effect on complications that result from hyperglycemia. Finally, a paper published in 2018 discussed how it exerted a hypoglycemic effect by “improving insulin signaling and preventing beta-cell failure.”30

Saffron Works as Well as a Drug to Treat ADHD

Attention deficit hyperactivity disorder (ADHD) is a commonly diagnosed neuropsychiatric disorder that affects 5% to 10% of school-age children.31 The children experience a mix of symptoms, from difficulty concentrating and hyperactivity to mood swings and short attention span.

The standard medical approach is a central nervous system stimulant drug such as methylphenidate (Ritalin). However, as with many medications, it causes significant side effects that impact the child's ability to function, including difficulty sleeping, loss of appetite and nausea.32

Some children and adults are not responsive to central nervous system stimulants to treat their symptoms of ADHD.33 In a six-week, randomized double-blind study,34 researchers engaged 50 children from age 6 to 17 years who completed the study. They were randomly assigned to receive methylphenidate or saffron capsules to treat their symptoms of ADHD.

The children's behavior was monitored using the Teacher & Parent ADHD Rating Scale, and the researchers found that methylphenidate and saffron had the same effect on ADHD symptoms. They noted that “short-term therapy with saffron showed the same efficacy compared with methylphenidate,”35 adding that the frequency of the adverse effects was also similar. They continued:36

“Taken together, since saffron is a ‘putative’ antidepressant and antidepressant agents are acceptable for treatment of ADHD, we hypothesized that saffron intake would be of benefit in these patients. In addition, having the ability to affect both monoaminergic and glutamatergic systems also qualify saffron as a possible candidate for the treatment of ADHD due to malfunction of these circuits in this disorder.”

Protective Strategies Against Alzheimer’s Disease

Research evidence has demonstrated there are several factors that impact the development and progression of Alzheimer's disease. This means there are several different strategies you can use to help protect your brain health and reduce your risk. I have written about many of these strategies, and many of them involve your nutritional habits.

As discussed earlier, there is a significant link between insulin resistance in the brain, also called Type 3 diabetes, and the development of Alzheimer's disease. You can reduce your risk by avoiding net carbohydrates, processed foods and sugars that spike your blood glucose and negatively impact your mitochondrial function. Following a cyclical ketogenic diet with intermittent fasting also has a powerful effect on your metabolism.

Research studies have looked at the effect a singular dietary change has on the development of Alzheimer's disease. One of those is the neuroprotective effect that long-term coffee drinkers experience. As I discuss in “Can Coffee Reduce Your Risk of Alzheimer's Disease?” evidence suggests that drinking coffee can lower your risk and reduce your overall cognitive decline.

Sulforaphane has a significantly beneficial effect on the brain as demonstrated in an initial study in patients with schizophrenia37 and an Alzheimer animal study.38 Evidence from animal models39 demonstrates that sulforaphane clears the accumulation of amyloid-beta and tau and improves memory deficits.

Cruciferous vegetables, and especially broccoli and broccoli sprouts, are high in sulforaphane as I discuss in “Sulforaphane for Your Heart and Brain.” Evidence also links your gut health and Alzheimer's disease, finding proteins produced by gut bacteria may trigger the development of the disease.

While scientists still have a lot to learn about the central nervous system and neurodegenerative diseases, it is apparent from recent evidence that the decisions you make today can have a significant effect on your potential risk for developing diseases. I encourage you to take simple steps that can have long-term results and to share the information you learn here with your friends and family.

Source : Mercola More   

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