Lab Just Made a More Dangerous COVID Virus

If SARS-CoV-2 has frazzled your nerves, I have bad news for you. Scientists are already cooking up more virulent and lethal versions. In a January 22, 2021, Twitter post, biotech entrepreneur Yuri Deigin highlighted a study posted on the preprint server bioRxiv at the end of December 2020, saying:1 “Ok, the prize for the craziest and most dangerous gain-of-function research goes out to Italian virologists who took SARS[-CoV-]2 and passaged it in vitro in the presence of neutralizing antibodies.2 It quickly obliged and mutated to escape them. Yay for a novel, more dangerous SARS3!” “Passaging” refers to a genetic engineering technique where a virus is grown in a series of different animal tissue cultures. With each “pass,” the virus will mutate slightly, gaining different functions. Serial Passaging Allows Virus to Jump Species As just one example, a potential outcome of this somewhat crude technique (considering the genetic engineering technology now available) would be that the virus could gain the ability to infect a host species it could not infect before. Some experts have speculated that this might be one way in which SARS-CoV-2 was created. In an in-depth article3 published in New York magazine January 4, 2021, Nicholson Baker reviewed the history of viral gain-of-function research, providing the following example of serial passaging: “Baric … described in this early paper how his lab was able to train a coronavirus, MHV, which causes hepatitis in mice, to jump species, so that it could reliably infect BHK (baby-hamster kidney) cell cultures. They did it using serial passaging: repeatedly dosing a mixed solution of mouse cells and hamster cells with mouse-hepatitis virus, while each time decreasing the number of mouse cells and upping the concentration of hamster cells. At first, predictably, the mouse-hepatitis virus couldn’t do much with the hamster cells, which were left almost free of infection, floating in their world of fetal-calf serum. But by the end of the experiment, after dozens of passages through cell cultures, the virus had mutated: It had mastered the trick of parasitizing an unfamiliar rodent. A scourge of mice was transformed into a scourge of hamsters …” Scientists Have Created Coronavirus That Escapes Antibodies So, what exactly have they come up with now? As summarized by Deigin, researchers serial passaged live SARS-CoV-2 in plasma obtained from a recovered COVID-19 patient that had a high amount of neutralizing antibodies in it.4 For clarification, you have two types of antibodies. Neutralizing antibodies are, as the name implies, antibodies that neutralize (kill) viruses and prevent infection, whereas binding antibodies cannot prevent infection. The neutralizing antibodies in the plasma successfully and completely neutralized the virus during the first seven passages, but then, the virus mutated to evade the antibodies. As explained by the authors:5 “The plasma fully neutralized the virus for 7 passages, but after 45 days, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed at day 80 by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization.” In other words, they created a SARS-CoV-2 variant that bypasses acquired immunity and negates the immunity you normally would have after recovering from the infection. As such, it could be extremely lethal. “Computational modeling predicts that the deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies,” the authors say, adding: “The recent emergence in the United Kingdom and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed.” Selective Pressure of Vaccination May Pose a Problem Now, further down in the paper, they point out that the reason they did this study was to determine “whether the authentic virus, under the selective pressure of the polyclonal immune response in convalescent or vaccinated people, can evolve to escape herd immunity and antibody treatment.” Since the virus can mutate to evade neutralizing antibodies, then it could potentially mutate under the “selective pressure” of vaccination as well, which in turn raises the question: If we mass vaccinate, will we end up with a more lethal virus? The solution these researchers seem to propose is to start thinking about vaccinating people for emerging SARS-CoV-2 variants, meaning we may need to develop a new vaccine — much like the seasonal flu vaccine, — to match the circulating strains of each season. Considering the first COVID-

Lab Just Made a More Dangerous COVID Virus

If SARS-CoV-2 has frazzled your nerves, I have bad news for you. Scientists are already cooking up more virulent and lethal versions. In a January 22, 2021, Twitter post, biotech entrepreneur Yuri Deigin highlighted a study posted on the preprint server bioRxiv at the end of December 2020, saying:1

“Ok, the prize for the craziest and most dangerous gain-of-function research goes out to Italian virologists who took SARS[-CoV-]2 and passaged it in vitro in the presence of neutralizing antibodies.2 It quickly obliged and mutated to escape them. Yay for a novel, more dangerous SARS3!”

“Passaging” refers to a genetic engineering technique where a virus is grown in a series of different animal tissue cultures. With each “pass,” the virus will mutate slightly, gaining different functions.

Serial Passaging Allows Virus to Jump Species

As just one example, a potential outcome of this somewhat crude technique (considering the genetic engineering technology now available) would be that the virus could gain the ability to infect a host species it could not infect before. Some experts have speculated that this might be one way in which SARS-CoV-2 was created.

In an in-depth article3 published in New York magazine January 4, 2021, Nicholson Baker reviewed the history of viral gain-of-function research, providing the following example of serial passaging:

“Baric … described in this early paper how his lab was able to train a coronavirus, MHV, which causes hepatitis in mice, to jump species, so that it could reliably infect BHK (baby-hamster kidney) cell cultures.

They did it using serial passaging: repeatedly dosing a mixed solution of mouse cells and hamster cells with mouse-hepatitis virus, while each time decreasing the number of mouse cells and upping the concentration of hamster cells.

At first, predictably, the mouse-hepatitis virus couldn’t do much with the hamster cells, which were left almost free of infection, floating in their world of fetal-calf serum.

But by the end of the experiment, after dozens of passages through cell cultures, the virus had mutated: It had mastered the trick of parasitizing an unfamiliar rodent. A scourge of mice was transformed into a scourge of hamsters …”

Scientists Have Created Coronavirus That Escapes Antibodies

So, what exactly have they come up with now? As summarized by Deigin, researchers serial passaged live SARS-CoV-2 in plasma obtained from a recovered COVID-19 patient that had a high amount of neutralizing antibodies in it.4

For clarification, you have two types of antibodies. Neutralizing antibodies are, as the name implies, antibodies that neutralize (kill) viruses and prevent infection, whereas binding antibodies cannot prevent infection.

The neutralizing antibodies in the plasma successfully and completely neutralized the virus during the first seven passages, but then, the virus mutated to evade the antibodies. As explained by the authors:5

“The plasma fully neutralized the virus for 7 passages, but after 45 days, the deletion of F140 in the spike N-terminal domain (NTD) N3 loop led to partial breakthrough. At day 73, an E484K substitution in the receptor-binding domain (RBD) occurred, followed at day 80 by an insertion in the NTD N5 loop containing a new glycan sequon, which generated a variant completely resistant to plasma neutralization.”

In other words, they created a SARS-CoV-2 variant that bypasses acquired immunity and negates the immunity you normally would have after recovering from the infection. As such, it could be extremely lethal.

“Computational modeling predicts that the deletion and insertion in loops N3 and N5 prevent binding of neutralizing antibodies,” the authors say, adding:

“The recent emergence in the United Kingdom and South Africa of natural variants with similar changes suggests that SARS-CoV-2 has the potential to escape an effective immune response and that vaccines and antibodies able to control emerging variants should be developed.”

Selective Pressure of Vaccination May Pose a Problem

Now, further down in the paper, they point out that the reason they did this study was to determine “whether the authentic virus, under the selective pressure of the polyclonal immune response in convalescent or vaccinated people, can evolve to escape herd immunity and antibody treatment.”

Since the virus can mutate to evade neutralizing antibodies, then it could potentially mutate under the “selective pressure” of vaccination as well, which in turn raises the question: If we mass vaccinate, will we end up with a more lethal virus?

The solution these researchers seem to propose is to start thinking about vaccinating people for emerging SARS-CoV-2 variants, meaning we may need to develop a new vaccine — much like the seasonal flu vaccine, — to match the circulating strains of each season.

Considering the first COVID-19 mRNA vaccines (which are most accurately described as gene therapy) are wreaking absolute havoc on people’s health already, in many instances killing the patient within hours (although health officials adamantly claim their deaths have nothing to do with the vaccines), the idea of implementing a twice-a-year gene-therapy regimen against COVID-19 strikes me as assured destruction of the human race.

Is SARS-CoV-2 Result of Gain-of-Function Research in Wuhan?

Jamie Metzl is ageopolitics expert, World Health Organization adviser and senior fellow at the Atlantic Council. January 4, 2021, CBS News interviewed her about the “conspiracy theory” that SARS-CoV-2 was created in a biosecurity level 4 laboratory in Wuhan, China. Metzl believes the COVID-19 pandemic is the result of an accidental leak from that lab.

This, he says, is a logical conclusion based on the facts before us. First, Wuhan is far from the southern part of China where horseshoe bats (the supposed source host) exist.

Second, the Wuhan Institute of Virology (WIV) was known to have performed controversial gain-of-function research on bat coronaviruses and, according to U.S. diplomats who had visited the lab in 2018, significant safety shortcomings were apparent.6

Third, SARS-CoV-2’s closest relative (RaTG13) has been traced back to samples collected in 2012 from miners sickened after working in an abandoned mine in Mojiang. There’s no trace of the virus anywhere between 2012 and 2019, until it suddenly caused an outbreak in Wuhan.

Lastly, “We see this massive Chinese cover-up,” Metzl says, “destroying samples, shutting off access to databases, imprisoning journalists [and] silencing scientists.”

On top of that, Metzl points out that scientists working at the WIV have been unable to account for all the viruses in their database, and level 4 biosecurity laboratories around the world have experienced many safety breaches in the past.

Investigative Committees Are Severely Compromised

As noted by Metzl — who also recently published an op-ed about this in Newsweek — what we need is a full, independent, all-access forensic investigation into the origin of this virus. If we don’t, we will not be ready for whatever else that might be right around the corner.

He also warns that while the WHO has assembled a committee7 to investigate, China was granted veto power to decide who would be on that committee, and the primary investigation is to be carried out by Chinese representatives. The WHO’s committee will then simply review their findings. This questionable setup makes it highly unlikely that we’ll get to the truth.

Indeed, the members of the WHO’s investigative committee raises serious concerns about its ability to conduct an unbiased investigation. One of its members, Peter Daszak, Ph.D., is the president of EcoHealth Alliance, a nonprofit organization that has worked closely with the WIV.

When SARS-CoV-2 first emerged in Wuhan, the EcoHealth Alliance was actually providing funding to the WIV to collect and study novel bat coronaviruses. He has publicly and repeatedly dismissed the possibility of the pandemic being the result of a lab leak.8

Daszak Is the Fox Guarding the Hen House

Importantly, correspondence obtained by U.S. Right to Know (USRTK) show Daszak played a central role in the plot to obscure the lab origin of SARS-CoV-2 from the very beginning by crafting a scientific statement condemning such inquiries as “conspiracy theory.”9,10

This manufactured “consensus” was then relied on by the media to counter anyone presenting theories and evidence to the contrary. Daszak is also heading up a second commission to investigate the origin of the virus, The Lancet COVID-19 commission,11 thereby ensuring that the “consensus” will be maintained.

Ironically, in 2015, Daszak actually warned a global pandemic might occur from a laboratory incident and that “the risks were greater with the sort of virus manipulation research being carried out in Wuhan.”12 Earlier that year, he was also a key speaker at a National Academies of Science seminar on reducing risk from emerging infectious diseases.

Among the material Daszak presented at that meeting was a paper titled, “Assessing Coronavirus Threats,” which included an examination of the “spillover potential” from “genetic and experimental studies” on viruses. In particular, he highlighted the danger of experimenting on “humanized mice,” meaning lab mice that have been genetically altered to carry human genes, cells or tissues.

Considering Daszak’s personal involvement with gain-of-function research in general, and research efforts at WIV in particular, he has more than enough motivation to make sure the blame for the COVID-19 pandemic is not laid at the feet of researchers such as himself, especially those at WIV.

As long as he is part of these investigative committees, any conclusions they come up with will be suspect. In fact, according to reports, the WHO commission has no intention of investigating either the WIV13 or the lab escape theory!14

Links to US Commissioned Research

While most of the focus has been on the WIV, the U.S. and other Western nations are not without blame. In the video above, “The Next Revolution” host Steve Hilton reviews the origin of COVID-19, linking the outbreak to research around the world.

He starts reviewing research done by the Erasmus Centre in the Netherlands 10 years ago. There, they were able to get an influenza A/H5N1 virus to mutate and become airborne by injecting it into ferrets. This led to an explosion of gain-of-function virus research all around the world. Interestingly, that Dutch study was funded by none other than Dr. Anthony Fauci’s National Institute of Allergy and Infectious Diseases (NIAID).

While the original intent may have been noble — stay a step ahead of nature so we’re not surprised by natural mutations that might threaten the human population — by creating more virulent pathogens, the work itself ends up posing significant risk.

This was why, in 2014, the Obama administration put a moratorium on gain-of-function research after recent biosafety incidents had highlighted the risky nature of such study. The moratorium included pausing gain-of-function research on influenza, MERS and SARS viruses.

However, as noted by Hilton, Fauci has long been a steadfast advocate of this kind of research, and shortly before the moratorium was put into place, he had funded a project to assess the risk of bat coronavirus emergence and the “spillover potential at high-risk human-wildlife interfaces in China.” At the end of that project description, they state:

“Predictive models of host range (i.e. emergence potential) will be tested experimentally using reverse genetics, pseudovirus and receptor binding essays, and virus infection experiments across a range of cell cultures from different species and humanized mice.”

This is precisely the kind of research the Obama administration placed a moratorium on, but Fauci didn’t drop it. Instead, he contracted it out to the EcoHealth Alliance — the group run by Daszak. Daszak himself was the project leader. Over the next six years, EcoHealth Alliance received $3.75 million for projects relating to this investigation.

Fauci, Daszak and the WIV Appear To Be Key Culprits

Daszak, in turn, subcontracted out a key piece of the research — the gain-of-function part — to the WIV. In his report, Hilton reviews some of the papers published throughout this project, proving they were indeed part of the research Fauci funded.

He points out that while many admit the NIAID funded the WIV in general, a paper co-written by Daszak and Shi Zhengli, proves Fauci funded gain-of-function research on bat coronavirus specifically.

After Hilton’s team reached out to the NIH and Fauci for comment, the paper mysteriously disappeared. The paper in question, published in 2017, shows they built various chimeras based on bat coronaviruses collected. They then infected human cells with these chimeras in the lab, proving that their manmade viruses could replicate.

The genetic changes they made to these chimeras “unlocked a specific doorway to the human body,” Hilton explains, and this doorway is precisely the one SARS-CoV-2 uses, namely the ACE2 receptor.

While none of the genetically engineered viruses described in that 2017 paper is identical to SARS-CoV-2, the paper proves it’s possible to create these kinds of viruses using current technologies. What’s more, that project continued for another three years, which puts us into 2020. During those three years, any number of new variants may have been created.  

In light of the evidence, Fauci’s role as chief medical adviser to the White House and leader of the coronavirus task force is “completely untenable,” Hilton says. Indeed, his conflicts of interest make Fauci just as unsuitable for these roles as Daszak is for the ones he’s been assigned to.

They’re both involved up to their eyeballs in the research that may be the very source of this pandemic, yet both have been placed in key roles to inform, guide and direct the public on these matters. It’s scientific corruption at its finest.

Surely, there are other experts out there who would be just as, if not more, qualified for these roles. “Fauci must step aside until we get to the bottom of his role in creating — unintentionally, of course — this catastrophic global pandemic,” Hilton says. We also need to know whether the U.S. government is still funding research that could lead to another, even more devastating pandemic.

Source : Mercola More   

What's Your Reaction?

like
0
dislike
0
love
0
funny
0
angry
0
sad
0
wow
0

Next Article

U.S. Coronavirus Deaths surpass 450,000 With the Daily Toll Still Stubbornly High

Daily deaths remain stubbornly high at more than 3,000 a day, despite falling infections and the arrival of multiple vaccines.

U.S. Coronavirus Deaths surpass 450,000 With the Daily Toll Still Stubbornly High

Coronavirus deaths in the United States surpassed 450,000 on Thursday, and daily deaths remain stubbornly high at more than 3,000 a day, despite falling infections and the arrival of multiple vaccines.

Infectious disease specialists expect deaths to start dropping soon, after new cases hit a peak right around the beginning of the year. New COVID-19 deaths could ebb as early as next week, said the new director of the Centers for Disease Control and Prevention.

But there’s also the risk that improving trends in infections and hospitalizations could be offset by people relaxing and coming together — including this Sunday, to watch football, she added.

“I’m worried about Super Bowl Sunday, quite honestly,” Dr. Rochelle Walensky said Thursday in an interview with The Associated Press.

Walensky said one reason cases and hospitalizations are not rising as dramatically as they were weeks ago is because the effect of holiday gatherings has faded.

The effect on deaths is delayed. The daily toll amounts to 50,000 new fatalities in the last two weeks alone.

“We’re still in quite a bad place,” she said.

The nation reported 3,912 COVID-19 deaths Wednesday, down from the pandemic peak of 4,466 deaths on Jan. 12.

The biggest driver to the U.S. death toll over the past month has been California, which has averaged more than 500 deaths per day in recent weeks.

Dora Padilla was among the thousands of Californians who died in the last month.

The 86-year-old daughter of Mexican immigrants served two decades as a schools trustee for Southern California’s Alhambra Unified School District after helping out as a parent volunteer and band booster for her own children. She was one of few Latinos to hold elected office at the time.

She tested positive in December at the facility where she lived, then developed a fever and saw her oxygen level drop. The facility was going to call an ambulance but decided to treat her there amid a surge in infections that filled local hospitals with virus patients, said her daughter Lisa Jones.

“They were just about ready to call an ambulance, but they realized there is nowhere for her to go. She is going to end up in a hallway somewhere,” Jones said.

Padilla was stable for days and seemed to be improving, but suddenly grew ill again before she died.

“I am still just kind of numb,” her daughter said.

California’s experience has mirrored many of the inequalities that have been exposed since the pandemic began nearly a year ago, with people of color being hit especially hard.

For example, Latinos make up 46% of California’s overall death toll, despite being 39% of the state’s population. The situation has worsened in recent months. In November, the daily number of Latino deaths was 3.5 per 100,000 residents, but that rate shot up to 40 deaths per 100,000 last week.

Alabama is another hot spot. The seven-day rolling average of deaths there has risen over the past two weeks, from 74 to 147 deaths per day. Kentucky, North Carolina, Oklahoma, South Carolina and Tennessee also saw surges in deaths.

The hardest hit demographic groups continue to be the oldest and frailest, said Dr. Thomas Holland of Duke University.

When coronavirus first swept through the country, it was concentrated in nursing homes, prisons and other congregate care settings. It later spread more broadly.

“But deaths have still been concentrated among older patients and patients” with other health problems, Holland said. “Even as the pandemic has spread more broadly in the population, the demographics of who dies from COVID has not really changed.”

In Florida, for instance, 83 percent of deaths attributed to the virus have been in people 65 and older.

Still, that hasn’t been enough to inspire some people to wear masks. A recent viral video from Oakes Farms Seed to Table, a local grocery store in Naples, Florida, showed both maskless customers and employees, chatting and laughing, without any social distancing.

Alfie Oakes, the store’s owner, told NBC’s “Today” show he knows masks do not work, and he does not believe the coronavirus has killed hundreds of thousands of people in the United States.

“That’s total hogwash,” Oakes said, adding: “Why don’t we shut the world down because of the heart attacks? Why don’t we lock down cities because of heart attacks?”

He did not return a call from the AP on Thursday.

Public health experts are watching Florida closely this week, because the Super Bowl will be played in Tampa. City leaders and the NFL are trying to ensure social distancing by capping attendance at a third of the stadium’s capacity — 22,000 people. Still, there will be parties, events at bars and clubs, and other activities that draw people together.

While most people who become infected will recover, others face a much longer road. It can take a week or two to get sick enough to end up in the hospital. Then, those who are severely ill may end up in an ICU for many weeks, and some will die.

“The patients who don’t do well are often in for these long and very stormy courses, and the patients who die, that’s typically weeks into their hospital stay,” Holland said.

Treatments have evolved for COVID over time, but there have not been any “game-changing miracle treatments” on par with the development of the vaccine, Holland said.

“We’ve had things on the margin that are helpful,” Holland said.

Among those, the use of steroids for patients who require oxygen, different ventilator strategies and preventing and managing blood clots. There’s also the use of monoclonal antibodies for outpatients early in their illness who do not need to be on oxygen, but who might be at higher risk of complications.

In addition, changes in testing have helped.

“Clearly, if people know they’re infected, they’re going to be more likely to do the things they need to do, like staying at home and quarantining or isolating,” he said.

Looking forward, the big concern is how the virus is changing, shifting into new strains that are potentially more infectious and better able to evade antibody products or to make vaccines less effective.

“We’ve always been in a race,” Holland said. “But it’s a lot more obvious now that we’re in a race to vaccinate people fast enough to slow down transmission, so that the virus has fewer opportunities to mutate and change and create these strain problems for us.”

___

Associated Press writers Mike Stobbe in New York City and Tamara Lush in St. Petersburg, Florida, contributed to this report.

Source : Time More   

This site uses cookies. By continuing to browse the site you are agreeing to our use of cookies.