Patents Prove SARS-CoV-2 Is a Manufactured Virus

In a January 2021 lecture, Jonathan Latham, Ph.D., introduced the term "the pandemic virus industrial complex," to describe the academic, military and commercial complexes that are driving the pandemic agenda and obscuring facts that indicate SARS-CoV-2 is a manmade virus. In the video above, David E. Martin, Ph.D., introduces shocking evidence that SARS-CoV-2 is indeed a manmade bioweapon, and has been in the works for decades. Much of this research was funded by none other than the National Institutes of Allergy and Infectious Diseases (NIAID) under the direction of Dr. Anthony Fauci. Pandemic virus industrial complex indeed! You do not want to miss this bombshell interview, conducted by Reiner Fuellmich,1 founding member of the German Corona Extra-Parliamentary Inquiry Committee2,3 (Außerparlamentarischer Corona Untersuchungsausschuss or ACU4). A transcript5 is available if you prefer to read it. SARS-CoV-2 Is Not a Novel Coronavirus at All Martin has been in the business of tracking patent applications and approvals since 1998. His company, M-Cam International Innovation Risk Management, is the world's largest underwriter of intangible assets used in finance in 168 countries. M-Cam has also monitored biological and chemical weapons treaty violations on behalf of the U.S. government, following the anthrax scare in September 2001. According to Martin, there are more than 4,000 patents relating to the SARS coronavirus. His company has also done a comprehensive review of the financing of research involving the manipulation of coronaviruses that gave rise to SARS as a subclade of the beta coronavirus family. In his testimony to ACU, he reviews some of the most pertinent patents, showing SARS-CoV-2 is not a novel coronavirus at all but, rather, a manmade virus that has been in the works for decades. And what we found … are over 120 patented pieces of evidence, to suggest that the declaration of a 'novel coronavirus' was actually entirely a fallacy. There was no novel coronavirus ... it's not been novel for over two decades. ~ David Martin, Ph.D.A comprehensive list of 120 patents relating to SARS-CoV-2-associated features can be found here.6 The features patented are referenced in two key scientific papers, "A Novel Bat Coronavirus Reveals Natural Insertions at the S1/S2 2 Cleavage Site of the Spike Protein and a Possible Recombinant 3 Origin of HCoV-19," and "The Proximal Origin of SARS-CoV-2." On that list, we see numerous patents detailing manipulation of the polybasic cleavage site for SARS-CoV, the spike protein, as well as ACE2 binding, all three of which are supposed to be unique features of SARS-CoV-2. As explained by Martin: "We took the reported gene sequence, which was reportedly isolated as a novel virus, indicated as such by the ICTV, the International Committee on Taxonomy of Viruses of the World Health Organization. We took the actual genetic sequences that were reportedly novel and reviewed those against the patent records that were available as of the spring of 2020. And what we found, as you'll see in this report, are over 120 patented pieces of evidence, to suggest that the declaration of a 'novel coronavirus' was actually entirely a fallacy. There was no novel coronavirus. There are countless, very subtle modifications of coronavirus sequences that have been uploaded, but there was no single identified 'novel coronavirus' at all. As a matter of fact, we found records in the patent records, of sequences attributed to novelty, going to patents that were sought as early as 1999. So not only was this not a novel anything … it's not been novel for over two decades." Spike Protein Vaccine for Coronavirus Patented 22 Years Ago Up until 1999, coronavirus patents were all in the veterinary sciences. The first coronavirus vaccine to use the S spike protein was patented by Pfizer in January 2000 (Patent No. 6372224). It was a spike protein virus vaccine for canine coronavirus. You can look up the actual patents for yourself on the United States Patent and Trademark Office's website,7 if you like. "Ralph Baric's work on … rabbit cardiomyopathy … and then canine coronavirus in Pfizer's work, to identify how to develop S spike protein vaccine target candidates, [give] rise to the obvious evidence that … … neither the coronavirus concept of a vaccine, nor the principle of the coronavirus itself, as a pathogen of interest with respect to the spike proteins behavior, is anything novel at all. As a matter of fact, it's 22 years old based on patent filings," Martin says. From HIV Vaccine Development to COVID-19 According to Martin, Fauci and the NIAID "found the malleability of coronavirus to be a potential candidate for HIV vaccines," and in 1999, Fauci funded research at University of North Carolina Chapel Hill (where Baric has a lab) to create "an infectious replication-defective coronavirus" specifically targeted for human lung epithelium.

Patents Prove SARS-CoV-2 Is a Manufactured Virus

In a January 2021 lecture, Jonathan Latham, Ph.D., introduced the term "the pandemic virus industrial complex," to describe the academic, military and commercial complexes that are driving the pandemic agenda and obscuring facts that indicate SARS-CoV-2 is a manmade virus.

In the video above, David E. Martin, Ph.D., introduces shocking evidence that SARS-CoV-2 is indeed a manmade bioweapon, and has been in the works for decades. Much of this research was funded by none other than the National Institutes of Allergy and Infectious Diseases (NIAID) under the direction of Dr. Anthony Fauci.

Pandemic virus industrial complex indeed! You do not want to miss this bombshell interview, conducted by Reiner Fuellmich,1 founding member of the German Corona Extra-Parliamentary Inquiry Committee2,3 (Außerparlamentarischer Corona Untersuchungsausschuss or ACU4). A transcript5 is available if you prefer to read it.

SARS-CoV-2 Is Not a Novel Coronavirus at All

Martin has been in the business of tracking patent applications and approvals since 1998. His company, M-Cam International Innovation Risk Management, is the world's largest underwriter of intangible assets used in finance in 168 countries. M-Cam has also monitored biological and chemical weapons treaty violations on behalf of the U.S. government, following the anthrax scare in September 2001.

According to Martin, there are more than 4,000 patents relating to the SARS coronavirus. His company has also done a comprehensive review of the financing of research involving the manipulation of coronaviruses that gave rise to SARS as a subclade of the beta coronavirus family.

In his testimony to ACU, he reviews some of the most pertinent patents, showing SARS-CoV-2 is not a novel coronavirus at all but, rather, a manmade virus that has been in the works for decades.

here.6 The features patented are referenced in two key scientific papers, "A Novel Bat Coronavirus Reveals Natural Insertions at the S1/S2 2 Cleavage Site of the Spike Protein and a Possible Recombinant 3 Origin of HCoV-19," and "The Proximal Origin of SARS-CoV-2."

On that list, we see numerous patents detailing manipulation of the polybasic cleavage site for SARS-CoV, the spike protein, as well as ACE2 binding, all three of which are supposed to be unique features of SARS-CoV-2. As explained by Martin:

"We took the reported gene sequence, which was reportedly isolated as a novel virus, indicated as such by the ICTV, the International Committee on Taxonomy of Viruses of the World Health Organization. We took the actual genetic sequences that were reportedly novel and reviewed those against the patent records that were available as of the spring of 2020.

And what we found, as you'll see in this report, are over 120 patented pieces of evidence, to suggest that the declaration of a 'novel coronavirus' was actually entirely a fallacy.

There was no novel coronavirus. There are countless, very subtle modifications of coronavirus sequences that have been uploaded, but there was no single identified 'novel coronavirus' at all.

As a matter of fact, we found records in the patent records, of sequences attributed to novelty, going to patents that were sought as early as 1999. So not only was this not a novel anything … it's not been novel for over two decades."

Spike Protein Vaccine for Coronavirus Patented 22 Years Ago

Up until 1999, coronavirus patents were all in the veterinary sciences. The first coronavirus vaccine to use the S spike protein was patented by Pfizer in January 2000 (Patent No. 6372224). It was a spike protein virus vaccine for canine coronavirus. You can look up the actual patents for yourself on the United States Patent and Trademark Office's website,7 if you like.

"Ralph Baric's work on … rabbit cardiomyopathy … and then canine coronavirus in Pfizer's work, to identify how to develop S spike protein vaccine target candidates, [give] rise to the obvious evidence that …

… neither the coronavirus concept of a vaccine, nor the principle of the coronavirus itself, as a pathogen of interest with respect to the spike proteins behavior, is anything novel at all. As a matter of fact, it's 22 years old based on patent filings," Martin says.

From HIV Vaccine Development to COVID-19

According to Martin, Fauci and the NIAID "found the malleability of coronavirus to be a potential candidate for HIV vaccines," and in 1999, Fauci funded research at University of North Carolina Chapel Hill (where Baric has a lab) to create "an infectious replication-defective coronavirus" specifically targeted for human lung epithelium.

The patent for that replication-defective coronavirus that attacks human lung cells was filed April 19, 2002 (Patent No. 7279327). "In other words, we made SARS," Martin says. Or perhaps more accurately, Fauci and UNC did. Several months after that patent filing, the SARS outbreak in Asia occurred.

"That patent, issued as U.S. Patent 7279327 … clearly lays out in very specific gene sequencing, the fact that we knew that the ACE receptor, the ACE2 binding domain, the S-1 spike protein, and other elements of what we have come to know as this scourge pathogen, was not only engineered, but could be synthetically modified in the laboratory using nothing more than gene sequencing technologies.

Taking computer code and turning it into a pathogen, or an intermediate of the pathogen, and that technology was funded exclusively, in the early days, as a means by which we could harness coronavirus as a vector to distribute HIV vaccine."

Coronavirus — A Biological Weapon Candidate Since 2001?

As mentioned, Martin has monitored biological and chemical treaty violations since 2001, following the anthrax attacks. Throughout the fall of 2001, an "enormous number" of bacterial and viral pathogens were patented through the National Institutes of Health, the NIAID, the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and their international collaborators.

"Our concern was that coronavirus was being seen as not only a potential manipulatable agent for potential use as a vaccine vector, but it was also very clearly being considered as a biological weapon candidate," Martin says.

Before the SARS outbreak in China, Martin reported these concerns publicly. "So, you can imagine how disappointed I am to be sitting here … having 20 years earlier pointed that there was a problem looming on the horizon with respect to coronavirus," he says.

CDC Holds Patents on SARS Coronavirus

In April 2003, after the SARS outbreak in China had occurred, the U.S. Centers for Disease Control and Prevention tried to file a patent for the entire gene sequence for the SARS coronavirus (Patent No. 7220852). This is a violation of 35 U.S. Code Section 101, which states you cannot patent a naturally-occurring substance.

That CDC patent also had several derivative patents associated with it, including U.S. patent 46592703P and U.S. patent 7776521. These two patents cover the gene sequence of SARS coronavirus and the means for detecting it using RT PCR testing.

Together, these patents are highly problematic, because if you own both, then "you have a cunning advantage to being able to control 100% of the provenance of not only the virus itself, but also its detection, meaning you have entire scientific and message control," Martin explains.

The CDC tried to justify the patent by saying they were being sought in order to ensure that everyone would be free to research coronaviruses. However, that is a lie, Martin says. The U.S. patent office rejected the patent on the gene sequence as unpatentable because it was 99.9% identical to a coronavirus that was already in the public domain.

The CDC paid an appeal fine in 2006 and again in 2007. They also paid an additional fee to keep the application private. In the end, the CDC overrode the patent examiner's rejection and secured the patent in 2007.

"Last time I checked, if you're trying to make information available for the public research, you would not pay a fee to keep the information private," Martin says. According to Martin, the gene sequence filed by the CDC in 2003, 2005 and 2006 is 89% to 99% identical to the sequence identified as SARS-CoV-2.

Sequoia Pharmaceuticals

April 28, 2003 — three days after the CDC filed its patent for the SARS coronavirus — Sequoia Pharmaceuticals filed a patent on an antiviral agent for the treatment and control of infectious coronavirus (Patent No. 7151163). So, the CDC files a patent on SARS coronavirus, and three days later there's a treatment?

This strongly suggests there was a working relationship behind the scenes. Sequoia Pharmaceuticals, founded in 2002, develops antiviral therapeutics with a special focus on drug-resistant viruses.8 Its lead investors include the Wellcome Trust.

But there's yet another problem with Sequoia's 2003 filing for an antiviral agent. It was actually issued and published before the CDC patent on SARS coronavirus had been granted, which didn't happen until 2007, and the CDC had paid to keep the application private.

"So, the degree to which the information could have been known by any means other than insider information between those parties is zero," Martin says. "It is not physically possible for you to patent a thing that treats a thing that had not been published, because CDC had paid to keep it secret.

This, my friends, is the definition of criminal conspiracy, racketeering and collusion. This is not a theory, this is evidence. You cannot have information in the future, and form a treatment for a thing that did not exist. It is a RICO case ...

And the RICO pattern, which was established in April of 2003 for the first coronavirus, was played out to exactly the same schedule when we see SARS COV-2 show up, when we have Moderna getting the spike protein sequence by phone from the vaccine research center at NIAID, prior to the definition of the novel subclade. How do you treat a thing, before you actually have the thing?"

Sanofi Holds Patents to Novel Feature of SARS-CoV-2

The next bombshell revelation occurred on June 5, 2008, when Ablynx, now a part of Sanofi, filed a series of patents detailing what we've been told are novel features of SARS-CoV-2, namely the polybasic cleavage site, the spike protein and the ACE2 receptor binding domain. The first of those patents, U.S. Patent No. 9193780, was issued November 24, 2015.

Between 2016 and 2019, a series of patents were issued to Ablynx and Sanofi covering the RNA strands and the subcomponents of the gene strands.

Between 2008 and 2017, a series of patents were also filed by a long list of players, including Crucell, Rubeus Therapeutics, Children's Medical Corporation, Ludwig-Maximilians-Universität in München, Protein Science Corporation, Dana-Farber Cancer Institute, University of Iowa, University of Hong Kong and the Chinese National Human Genome Center in Shanghai.

This series of patents detail ever single attribute that is supposed to be unique to SARS-CoV-2, according to the paper, "A Novel Bat Coronavirus Reveals Natural Insertions at the S1/S2 2 Cleavage Site of the Spike Protein and a Possible Recombinant 3 Origin of HCoV-19."

This paper has routinely been used to identify the so-called novel coronavirus that is SARS-CoV-2. Yet there are 73 patents, issued between 2008 and 2019, that describe the very elements that are said to be unique to SARS-CoV-2. Patents have been filed for SARS-CoV-2's polybasic cleavage site, the ACE2 receptor binding domain, and the spike protein.

"So, there was no 'outbreak' of SARS, because we had engineered all of the elements of that," Martin says. And by 2016, when Baric published a paper warning that SARS coronavirus was "poised for human emergence," the virus in question had already been patented for commercial exploitation 73 times!

The Pandemic Virus Industrial Complex Is Swimming in Profit

Baric is one of the few people who has profited significantly from this pandemic, which he appears to have been part of creating. Another is Fauci. The same drug companies that hold patents on not-so-novel SARS-CoV-2 features are also raking in profits from their COVID shots.

In 2015, Dr. Peter Daszak, head of the EcoHealth Alliance that funneled research dollars from the NIAID to the Wuhan Institute of Virology for coronavirus research, who has promoted the official narrative that SARS-CoV-2 has a natural origin, stated:9

"We need to increase public understanding of the need for medical countermeasures such as a pan-coronavirus vaccine. A key driver is the media and the economics will follow the hype. We need to use that hype to our advantage, to get to the real issues. Investors will respond if they see profit at the end of the process."

Sounds an awful lot like what we're facing right now, doesn't it? At the end of the day, this pandemic has primarily been about profit and the shifting of wealth, from the lower- and middle-classes to the already ultra-wealthy. This is a war on the public, waged using biological weapons and information warfare, with the ultimate goal of "resetting" life and commerce as we know it.

Intentional Weaponization of Spike Protein

Martin says:

"There wasn't a lab leak. This was an intentional bio-weaponization of spike proteins to inject into people, to get them addicted to a pan-coronavirus vaccine. This has nothing to do with a pathogen that was released, and every study that's ever been launched to try to verify a lab leak, is a red herring.

[There are] 73 patents on everything clinically novel — 73, all issued before 2019. And I'm going to give you the biggest bombshell of all to prove that this was actually not a release of anything, because Patent No. 7279327, the patent on the recombinant nature of that 'lung-targeting' coronavirus, was transferred mysteriously from the University of North Carolina Chapel Hill to the National Institutes of Health in 2018.

Now, here's the problem with that. Under the Bayh-Dole Act, the U.S. government already has what's called a march-in right provision. That means if the U.S. government has paid for research, they are entitled to benefit from that research at their demand or at their whim.

So, explain why, in 2017 and 2018, suddenly the National Institutes of Health have to take ownership of the patent that they already had rights to, held by the University of North Carolina Chapel Hill. And how did they need to file a Certificate of Correction to make sure that it was legally enforceable, because there was a typographical error in the grant reference in the first filing?

They needed to make sure that not only did they get it right, but they needed to make sure every typographical error that was contained in the patent was correct on THE SINGLE PATENT REQUIRED, to develop the Vaccine Research Institute's mandate, which was shared between the University of North Carolina Chapel Hill and Moderna in November of 2019, when UNC Chapel Hill, NIAID and Moderna began the sequencing of a spike protein vaccine — a month before an outbreak ever happened."

'New Normal' Coined by Merck at 2004 Bioterrorism Conference

The more we learn, the grimmer it gets. Clearly, plans for our current-day predicament were laid well over a decade ago. According to Martin, the slogan "The New Normal" was coined by Merck during a January 6, 2004, conference called "SARS and Bioterrorism, Emerging Infectious Diseases, Antimicrobial Therapeutics, and Immune Modulators."

This term has now become a branded campaign adopted by the World Health Organization, the Global Preparedness Monitoring Board and the rest of the pandemic virus industrial complex.

Incidentally, Fauci is on the board of directors of the Global Preparedness Monitoring Board, as is Dr. Chris Elias, president of the Global Development Program at the Bill & Melinda Gates Foundation, and George Fu Gao, Ph.D., director-general of the Chinese CDC and a Chinese communist party member.10

It's a long interview, but it does not disappoint. I urge you to take the time to listen to it, as Martin really lays out the timeline of when and how this pandemic virus came to be. He's also published a 205-page paper11 detailing Fauci's involvement that you can download from archive.org.

It now seems clearer than ever that everything we're experiencing was planned and executed with a profit motive in mind. Armed with this new knowledge, I urge you once again to reclaim your life, your freedom and independence, and resist this manufactured notion of a "new normal." A new normal will surely be established if we persist, but it will be the converse of what the pandemic virus industrial complex is hoping for.

We will resurrect medicine and science from the induced coma these fields are currently in, and usher in a new era of medical freedom, personal liberty, responsible and transparent government, fiscal stability and health care that actually promotes health rather than slow death. It may take a while, but together, we can do it. To get there, keep sharing information such as that provided by Martin in this mind-blowing interview in any way you can. In the end, truth will prevail. Believe it.

Source : Mercola More   

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Vitamin B12 Deficiency Symptoms

A significant portion of Americans have some type of vitamin deficiency, one of which is vitamin B12.1 Vitamin B12 (cobalamin) is a water-soluble vitamin, which is vital for optimal health. Unfortunately, many of the symptoms of deficiency mimic other health conditions and so it is often considered last in a variety of health issues. There are four known forms of the vitamin2 including methylcobalamin and 5-deoxyadenosylcobalamin, which are metabolically active. Two other forms, hydroxocobalamin and cyanocobalamin, become biologically active after they are converted. Vitamin B12 is an essential vitamin, which means your body cannot make it. Instead, you must consume an average of 2.4 micrograms each day from food or supplements.3 While it's found in a wide variety of animal foods,4 some experts estimate that 3.2% of people over age 50 are deficient in vitamin B12, and another possible 20% have a borderline deficiency5 and others estimate that up to 43% of older adults may be deficient.6 Although it affects a significant number of people, particularly the elderly and those in developing countries, it is one of the most overlooked conditions.7 Vitamin B12 plays a vital role in many functions throughout your body. For example, it is important to create blood cells and keep nerve cells healthy. Vitamin B12 also helps prevent megaloblastic anemia.8 The vitamin is necessary for cardiovascular and cognitive health, and it helps to produce hemoglobin, improve nerve strength and regulate homocysteine levels.9,10,11 Homocysteine is an amino acid produced by the body, which in large amounts can increase the risk of heart attack and stroke. One function of vitamin B12 is to help break down homocysteine in your blood.12 What symptoms might be a warning that you or a loved one may have a vitamin B12 deficiency? Symptoms of Vitamin B12 Deficiency Are Not Diagnostic The most common cause of megaloblastic anemia is a deficiency in vitamin B12.13 In this condition the bone marrow produces large and immature red blood cells, which leads to fatigue, lightheadedness and skin pallor. Other symptoms of vitamin B12 deficiency include:14,15,16,17 Shortness of breath Dizziness Difficulty breathing Loss of appetite Tingling or numbness in the hands or feet Balance or gait problems Loss of vision Mental confusion Memory loss Depression Insomnia Panic attacks Weight loss Infertility Dementia Mouth or tongue soreness Swollen or inflamed tongue Difficulty reasoning Joint pain Paranoia and delusions Incontinence Constipation Headache Heart palpitations (Feeling like your heart is pounding or racing) Infants who are deficient present with failure to thrive, megaloblastic anemia and delayed development.18 Permanent damage to the nervous system can occur, so identifying deficiency in people who don't first present with megaloblastic anemia is crucial, so it is treated as soon as possible. Although an experienced health care provider may recognize symptoms and theorize that you have a deficiency, testing is required to confirm the condition. Certain groups of people are at greater risk of developing a vitamin B12 deficiency than others. These groups of people have difficulty absorbing vitamin B12 from the food they eat, or they don't get enough in their diet.19 To absorb the vitamin your body goes through a two-step process. First, hydrochloric acid in your stomach separates the vitamin from protein in the food source. Next, vitamin B12 attaches with a protein your stomach makes — called intrinsic factor — so it can be absorbed into the body. In certain conditions, even people taking supplements cannot absorb the vitamin since they don't make enough intrinsic factor to bind with the vitamin so it can be absorbed. You may have a higher risk of developing a vitamin B12 deficiency if you are/have:20,21 An older adult — Age increases the potential you don't make enough hydrochloric acid. A regular coffee drinker — One study22 found those who drank four or more cups of coffee daily had lower plasma concentrations of circulating vitamin B concentrations. A regular alcohol drinker — The effect of regular alcohol consumption was measured in healthy, well-nourished, postmenopausal women,23 which demonstrated lower levels of vitamin B12, potentially since vitamin B12 is stored in the liver. On certain medications — Experts recommend “Special attention should also be given to patients on medications such as PPIs, H2-receptor antagonists, antacids, metformin, colchicine, cholestyramine, and patients chronically on anticonvulsants or antibiotics.”24 An autoimmune disease called atrophic gastritis — This condition decreases both the amount of hydrochloric acid and intrinsic factor needed to process and absorb the vitamin. Pernicious anemia — People with this type of anemia do not make intrinsic factor. This means they cannot absorb the vitamin from suppleme

Vitamin B12 Deficiency Symptoms

A significant portion of Americans have some type of vitamin deficiency, one of which is vitamin B12.1 Vitamin B12 (cobalamin) is a water-soluble vitamin, which is vital for optimal health. Unfortunately, many of the symptoms of deficiency mimic other health conditions and so it is often considered last in a variety of health issues.

There are four known forms of the vitamin2 including methylcobalamin and 5-deoxyadenosylcobalamin, which are metabolically active. Two other forms, hydroxocobalamin and cyanocobalamin, become biologically active after they are converted.

Vitamin B12 is an essential vitamin, which means your body cannot make it. Instead, you must consume an average of 2.4 micrograms each day from food or supplements.3 While it's found in a wide variety of animal foods,4 some experts estimate that 3.2% of people over age 50 are deficient in vitamin B12, and another possible 20% have a borderline deficiency5 and others estimate that up to 43% of older adults may be deficient.6

Although it affects a significant number of people, particularly the elderly and those in developing countries, it is one of the most overlooked conditions.7 Vitamin B12 plays a vital role in many functions throughout your body. For example, it is important to create blood cells and keep nerve cells healthy.

Vitamin B12 also helps prevent megaloblastic anemia.8 The vitamin is necessary for cardiovascular and cognitive health, and it helps to produce hemoglobin, improve nerve strength and regulate homocysteine levels.9,10,11

Homocysteine is an amino acid produced by the body, which in large amounts can increase the risk of heart attack and stroke. One function of vitamin B12 is to help break down homocysteine in your blood.12 What symptoms might be a warning that you or a loved one may have a vitamin B12 deficiency?

Symptoms of Vitamin B12 Deficiency Are Not Diagnostic

The most common cause of megaloblastic anemia is a deficiency in vitamin B12.13 In this condition the bone marrow produces large and immature red blood cells, which leads to fatigue, lightheadedness and skin pallor. Other symptoms of vitamin B12 deficiency include:14,15,16,17

Shortness of breath

Dizziness

Difficulty breathing

Loss of appetite

Tingling or numbness in the hands or feet

Balance or gait problems

Loss of vision

Mental confusion

Memory loss

Depression

Insomnia

Panic attacks

Weight loss

Infertility

Dementia

Mouth or tongue soreness

Swollen or inflamed tongue

Difficulty reasoning

Joint pain

Paranoia and delusions

Incontinence

Constipation

Headache

Heart palpitations (Feeling like your heart is pounding or racing)

Infants who are deficient present with failure to thrive, megaloblastic anemia and delayed development.18 Permanent damage to the nervous system can occur, so identifying deficiency in people who don't first present with megaloblastic anemia is crucial, so it is treated as soon as possible.

Although an experienced health care provider may recognize symptoms and theorize that you have a deficiency, testing is required to confirm the condition. Certain groups of people are at greater risk of developing a vitamin B12 deficiency than others. These groups of people have difficulty absorbing vitamin B12 from the food they eat, or they don't get enough in their diet.19

To absorb the vitamin your body goes through a two-step process. First, hydrochloric acid in your stomach separates the vitamin from protein in the food source. Next, vitamin B12 attaches with a protein your stomach makes — called intrinsic factor — so it can be absorbed into the body.

In certain conditions, even people taking supplements cannot absorb the vitamin since they don't make enough intrinsic factor to bind with the vitamin so it can be absorbed. You may have a higher risk of developing a vitamin B12 deficiency if you are/have:20,21

An older adult — Age increases the potential you don't make enough hydrochloric acid.

A regular coffee drinker — One study22 found those who drank four or more cups of coffee daily had lower plasma concentrations of circulating vitamin B concentrations.

A regular alcohol drinker — The effect of regular alcohol consumption was measured in healthy, well-nourished, postmenopausal women,23 which demonstrated lower levels of vitamin B12, potentially since vitamin B12 is stored in the liver.

On certain medications — Experts recommend “Special attention should also be given to patients on medications such as PPIs, H2-receptor antagonists, antacids, metformin, colchicine, cholestyramine, and patients chronically on anticonvulsants or antibiotics.”24

An autoimmune disease called atrophic gastritis — This condition decreases both the amount of hydrochloric acid and intrinsic factor needed to process and absorb the vitamin.

Pernicious anemia — People with this type of anemia do not make intrinsic factor. This means they cannot absorb the vitamin from supplements or their food and require vitamin B12 shots for treatment.

Stomach or intestinal surgery — For example, weight loss surgery may remove a large part of the stomach, and thus reduce the amount of hydrochloric acid and intrinsic factor to absorb vitamin B12.

Disorders of the stomach or small intestines — This includes celiac disease, Crohn's disease, tropical sprue or bacterial overgrowth.

Vegetarian or vegan — Vitamin B12 is only found naturally in animal foods such as meat, fish, dairy and eggs. Additionally, women who are strict vegetarians who are pregnant, or nursing do not give enough vitamin B12 to their babies.

Low Levels of B12 May Be Missed

Unless you have recognizable signs of vitamin B12 deficiency, your physician may not think to test your level. Yet, even when tested, serum norms in the U.S. may be suboptimal. Additionally, individual requirements can vary, so you may have symptoms of deficiency even when your serum levels appear to be in the normal range.25

Serum levels can also be altered by the presence or absence of binding proteins. Some serum tests identify inactive forms of cobalamin, which masks deficiencies of the active form of the vitamin.

Instead, researchers recommended evaluating deficiency through the measurement of metabolites, including homocysteine, or levels of cobalamin bound to holo-transcobalamin, which more accurately represents the active form of the vitamin.

Evidence suggests that relying on serum levels of vitamin B12 can significantly underestimate tissue deficiency by as much as 50%. Serum levels may be maintained as vitamin B12 is pulled from the tissue. This means that a value above the normal cut off point does not necessarily mean you have adequate levels of vitamin B12 for your body to use.

Researchers from this study and other experts26 suggest several other ways of more accurately predicting potential deficiency. One method is to look at the spectrum of metabolic abnormalities and clinical symptoms as compared against homocysteine and MMA levels.27

B12 Deficiency May Be an Underestimated Cause of Dementia

Some of the symptoms of vitamin B12 deficiency are mental health disorders, including depression. One study28 of 89 children and adolescents with depression found those who are depressed had “clearly low” levels of vitamin B12 and vitamin D and their homocysteine levels were “remarkably high.”

Another study29 engaged 199 depressed adults who received vitamin B12 supplementation with antidepressants and exhibited significantly improved symptoms. In addition to depression, low levels of vitamin B12 have been associated with minimal cognitive impairment and dementia and may be an option to improve patient outcomes.30

One study31 characterized the cognitive pattern of elderly adults who had vitamin B12 deficiency and compared it against those who had Alzheimer's disease. Their results suggested a distinctly different pattern in both diseases.

The researchers found that of the 19 individuals who had low levels of vitamin B12, 12 improved with treatment and seven continued to deteriorate. The researchers went on to analyze the initial neuropsychological evaluation of the two groups of patients and found there was a different profile in those who had a form of dementia that responded to vitamin B12 supplementation and those who did not.

In the group who responded to B12 supplementation there were initially more psychotic problems and a greater number of deficits in executive functioning and concentration. In the group who did not respond to supplementation there were greater problems with language and apraxia.

The scientists discovered memory pattern challenges were also different, leading them to believe that vitamin B12 deficiency may be differentiated from Alzheimer's disease with a thorough psychological evaluation.32

Scientists recognize that the hematological and neuropsychiatric effects of vitamin B12 deficiency may not occur systematically. The true incidence of neuropsychiatric symptoms is unknown. However, depending on the population being studied and the definition of vitamin B12 deficiency used by the researchers, the rate can vary between 4% and 50%.33

Testing for Vitamin B12 Deficiency With Cognitive Decline

As early as 2009, Dr. Ronald Devere, then-director of the taste and smell disorders clinic and Alzheimer's disease and memory disorders center in Austin, Texas, recommended guidelines for evaluating vitamin B12, folate, MMA and homocysteine blood levels to discern those who may respond to vitamin B12 or folate supplementation to reduce cognitive impairment.34

He recommended continuing to use vitamin B12 and folate serum levels in those who present with changes in cognitive functioning. In addition, he set limits for measuring MMA and homocysteine to determine if serum vitamin B12 was an accurate reflection of the vitamin level.

In one paper35 published in the Journal of Neuropsychiatry, the scientists recognized only one-third of individuals with low levels of vitamin B12 receive adequate supplementation. The researchers warned that in the early phases of replacement therapy in patients who have megaloblastic anemia, clinicians should watch for falling potassium levels that may result in early death.

Administering folate in conjunction with vitamin B12 supplementation may help partially correct megaloblastic anemia. On the other hand, they suggest it could aggravate encephalopathy that may be present with vitamin B12 deficiency.

The doctors suggest that the devastating impact of dementia on the individual and their family warrants testing for vitamin B12 deficiency and potentially supplementation, since deficiency in the elderly is a common condition and modern diagnostic tools in addition to neurophysiological parameters may help improve cognitive performance.

B Vitamins May Help Prevent the Worst COVID Outcomes

Vitamin B12 belongs to a complex of B vitamins which researchers’ postulate may significantly improve COVID-19 outcomes. One cohort study36,37 of 43 patients diagnosed with COVID-19 admitted to the Singapore General Hospital in early 2020 analyzed the oral administration of vitamin D3, magnesium and vitamin B12, collectively called DMB, against a control group who did not receive DMB therapy.

The researchers found that only 17.6% required oxygen therapy during hospitalization as compared to 61.5% of those in the control group. Of the patients who required oxygen in the DMB group, two were admitted to ICU and one was not. Of the control group that required supplemental oxygen, all were admitted to the ICU.

The B vitamins play a significant role in a healthy functioning immune system. Additionally, the same group of vitamins play a role in reducing the severe effects of COVID-19,38 including roles in viral replication, cytokines storm induction, adaptive immunity and hypercoagulability.

In one paper39 published in the journal Maturitas, scientists detailed the various routes that each of the B vitamin may affect in the management of COVID-19 symptoms. Specifically for vitamin B12, a deficiency can increase an inflammatory response and raise homocysteine levels.

These actions may trigger endothelial dysfunction and activate a platelet and coagulation cascade that can potentially lead to blood clots. For further explanation see “B Vitamins Might Help Prevent Worst COVID-19 Outcomes.”

Vitamin B12 is found almost exclusively in animal tissue. This includes foods like beef, lamb, venison, poultry, eggs and dairy products. Nutritional yeast is high in B12 and recommended for vegetarians and vegans. Two tablespoons provide 7.8 micrograms.40

A sublingual under the tongue fine mist spray or vitamin B12 injections are also effective as they allow the large molecule to be absorbed directly into your bloodstream and bypasses the need for hydrochloric acid and intrinsic factor.

Source : Mercola More   

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